U0126-EtOH

Product Name: U0126-EtOH
CAS No.: 1173097-76-1
Chemical Name: U0126-EtOH
Synonyms: u 126;Lemod;CS-2415;U0126-EtOH;Depo-Medrin;Depometicort;U0126 Ethanol;U0126-EtOH USP/EP/BP;U0126-ETOH;U 0126;U-0126;U0126-EtOH, a high selective MEK1/2 inhibitor
CBNumber: CB72561498
Molecular Formula: C20H22N6OS2
Formula Weight: 426.56
MOL File: 1173097-76-1.mol

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U0126-EtOH Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: ≥21.33 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid

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Safety

HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0173
Product name: U0126-EtOH
Purity: 98.70%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD43319
Product name: U 0126 monoethanolate
Packaging: 10mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: BISN0130
Product name: U0126 Ethanol
Packaging: 5mg
Price: $88
Updated: 2021/12/16

ApexBio Technology

Product number: A1337
Product name: U0126-EtOH
Packaging: 25mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-0173
Product name: U0126-EtOH
Purity: 98.70%
Packaging: 50mg
Price: $106
Updated: 2021/12/16

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U0126-EtOH Chemical Properties,Usage,Production

Uses

A chemically synthesized and highly selective inhibitor of both MEK1 and MEK2 with IC50s of 70 nM and 60 nM, respectively.

Definition

ChEBI: U0126.EtOH is an addition compound obtained by combining equimolar amounts of (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile (U0126) and ethanol. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, an antioxidant, an osteogenesis regulator and a vasoconstrictor agent. It contains an U0126.

Biological Activity

u0126-etoh is a selective inhibitor of mek1 and mek2 with ic50 values of 70 nm and 60 nm, resepctively [1].u0126 was screened out as an anti-inflammatory agent that inhibited ap-1 transcription with ic50 value of 1μm and had no interactions with gres. u0126 binds mek1/2 in a unique site. this inhibition of mek1/2 is noncompetitive with erk and atp. u0126 showed no effects on other mapkks. in ht22 cells, u0126 treatment significantly inhibited the cell injury caused by oxidative glutamate toxicity and remarkably blocked the phosphorylation of erk1/2. besides that, u0126 exerted no neuroprotection against other stimuli such as tnfα and actinomycin d. u0126 treatment also protected the primary cultured cortical neurons from oxidative glutamate toxicity and hypoxia/reoxygenation [1, 2].

target

MEK1

References

[1] duncia j v, santella iii j b, higley c a, et al. mek inhibitors: the chemistry and biological activity of u0126, its analogs, and cyclization products. bioorganic & medicinal chemistry letters, 1998, 8(20): 2839-2844.
[2] satoh t, nakatsuka d, watanabe y, et al. neuroprotection by mapk/erk kinase inhibition with u0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. neuroscience letters, 2000, 288(2): 163-166.

U0126-EtOH Preparation Products And Raw materials

Raw materials

Preparation Products

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U0126-EtOH Suppliers

China 95 India 1 The Netherlands 1 United States 13 Global 110

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

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View Lastest Price from U0126-EtOH manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: U0126-EtOH 1173097-76-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

1173097-76-1, U0126-EtOHRelated Search:

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CS-2415

u 126

2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile,ethanol

U0126-ETOH;U 0126;U-0126

(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile,ethanol

U0126-EtOH

2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile ethanol salt

(2Z,3Z)-2,3-Bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (1:1)

U0126-EtOH, 98%, a high selective MEK1/2 inhibitor

U0126 Ethanol

U0126-EtOH USP/EP/BP

Depo-Medrin

Depometicort

Lemod

U0126-EtOH, a high selective MEK1/2 inhibitor

2,3-Bis(amino((2-aminophenyl)thio)methylene)succinonitrile compound with ethanol (1:1)

Influenza Virus,Mitogen-activated protein kinase kinase,MAP2K,U-0126-EtOH,U0126-EtOH,MEK,inhibit,competitive,virus,Mitophagy,Autophagy,U0126EtOH,MAPKK,Mitochondrial Autophagy,Inhibitor,progeny,non-ATP,U0126 EtOH

1173097-76-1

C18H16N6S2C2H6O

Inhibitors

MAPK